Indication. Chondroplus is indicated for the relief of pain and improvement of joint mobility in patients with mild to moderate osteoarthritis of the knee, ankle and hip. It is administered by a registered medical practitioner as a single intra-articular injection.

Knee pain relief from one injection, for up to a year*

Chondroplus combines two things in a single syringe: hyaluronic acid to restore the cushioning fluid in your knee, and collagen tripeptide to reach the cartilage itself. Your doctor gives it in the clinic, in a few minutes.

Is it right for me?Prepare for my doctor

Reganemed product information and internal data report 9 months to 1 year from a single injection. The published clinical study followed patients to 6 months. Individual results vary.

Chondroplus intra-articular injection: a 2 ml prefilled syringe of hyaluronic acid with collagen tripeptide beside its carton

Is it right for me?

An injection is not usually the first thing to try. It is for a knee that is still limiting you after the simpler options. Only your doctor can say whether it suits yours, but this is the conversation to have.

Worth asking about if

You have been told you have osteoarthritis of the knee, ankle or hip
Pain still limits you despite painkillers, exercise or physiotherapy
You would rather have one injection than a course of three to five
A previous hyaluronic acid injection helped but wore off too quickly
You would prefer a treatment with no animal-derived ingredients

Not suitable, or check first, if

There is an infection in the joint, or a wound or rash over it
You have had a reaction to any of its ingredients
You take blood thinners: tell your doctor before any injection
You are pregnant or breastfeeding: safety has not been established
Your knee is hot, swollen and very painful today: that needs assessing first

How it works

Osteoarthritis goes wrong in two places at once: the fluid that cushions the joint, and the cartilage it protects. Most injections only treat the first.

A healthy knee is full of thick, slippery fluid. It cushions every step you take.

Hyaluronic acid
Collagen tripeptide
Chondrocyte, the cell that maintains cartilage
Enzyme, eating the hyaluronic acid

Thick fluid, smooth surface, working cells

Long chains of hyaluronic acid make the joint fluid thick and slippery, so the cartilage glides and the knee absorbs shock. Inside the cartilage, chondrocytes rebuild the matrix as fast as it wears down.

In the fluid:: Long chains, fluid thick and slippery
In the cartilage:: Chondrocytes keeping up with the wear

Schematic, not to scale. Neither ingredient regrows cartilage that has already been lost: collagen tripeptide supports the cells that maintain the matrix, which is not the same thing. Duration figures come from Reganemed product information; the published study followed patients to six months.

Nothing in it comes from an animal

Some hyaluronic acid injections are extracted from avian tissue, and their labelling warns anyone allergic to birds, feathers, eggs or poultry. The hyaluronic acid in Chondroplus is produced by bacterial fermentation, and its collagen tripeptide is made synthetically.

That matters for allergy, and for many patients in Malaysia it matters for dietary and religious reasons too. For formal certification status, ask your clinic or us for the current documentation.

Manufactured by: Reganemed GmbH, Frankfurt am Main
Conformity: CE marked, sterile, single use
Source: Bacterial fermentation, non-animal
Supplied in Malaysia by: AA Alive Sdn. Bhd. (EVIN)

What to expect

It is usually given by an orthopaedic surgeon, a sports physician or a rheumatologist, in the clinic. The injection itself takes a few minutes.

Before your appointment
Note how long your knee has hurt, what makes it worse, and what you have already tried. The discussion guide below does this for you. Tell the doctor about any blood thinners.
On the day
The doctor examines the knee, often with an X-ray and ultrasound. If the joint is swollen, excess fluid is drained first. The full 2 ml is then injected, ideally under ultrasound guidance so it lands in the joint space.
The first 48 hours
Walk normally, but avoid running, squatting and heavy lifting. Mild aching or warmth for a day or two is common and settles with ice. What is normal and what is not.
The weeks after
It is not a painkiller, so the change builds gradually. Most people notice a difference within two to six weeks.
Making it last
Use the comfortable months to build the thigh muscle that protects the joint. Five exercises that are worth the time.

How long relief lasts

A conventional hyaluronic acid injection is cleared from the joint within months. Cross-linking slows the enzymes that break it down, which is what extends the interval between visits.

Hatching marks the upper end of the reported range. Chondroplus duration: manufacturer product information and internal data. Conventional hyaluronic acid: Strauss et al., Am J Sports Med 2009;37(10):1636–1643. Individual results vary.

The published evidence

A 2024 study in Frontiers in Medicine followed a single ultrasound-guided injection of this combination in 29 patients whose knees typically respond worst: osteoarthritis with coexisting crystal deposits, median grade 3, mean age 70. Each dot below is one patient.

19 of 24

reached a clinically meaningful improvement in pain

79%. Porta et al. 2024, patients assessed at 6 months

20 of 24

reached it on the WOMAC function index

83%. Porta et al. 2024, patients assessed at 6 months

0 of 29

had an injection-related side effect recorded

Porta et al. 2024, all 29 patients injected

Scope of this claim. The 2024 study was retrospective, had no control group, and enrolled 29 patients with 6-month data for 24. It is supportive evidence, not proof of superiority over any other product.

Read the full summary, including what the study does not show

Prepare for your doctor

Appointments are short. Answer these eight questions and you walk in with your history organised, the things your doctor needs to know flagged, and the right questions ready.

1How long has your knee hurt?

2Which knee?

3How bad is it on a typical day?

0 is no pain, 10 is the worst you can imagine.

5/10

4What makes it worse?

Choose all that apply.

5How long does it stay stiff in the morning?

6What have you already tried?

Choose all that apply.

7Has your knee been X-rayed?

8Do any of these apply to you?

Your doctor needs to know these before any injection.

1 of 8 answered

My knee: notes for my doctor

Knee: Not answered
How long: Not answered
Typical pain: 5 out of 10
Worse with: Not answered
Morning stiffness: Not answered
Already tried: Not answered
X-ray: Not answered

Questions to ask

Is my pain coming from osteoarthritis, or could it be something else?
What grade is my knee, and what does that mean for treatment?
Would an injection help, and which type suits my knee?
If hyaluronic acid is an option, would a longer-acting one suit me?
Will the injection be guided by ultrasound?
What is the total cost, including the consultation?
Which exercises should I be doing alongside it?

Your own notes, organised for the appointment. Not a diagnosis.

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Which knee injection should I have?

It depends on what your knee is doing today. A corticosteroid settles a hot, swollen knee fastest, working in one to three days but lasting only four to twelve weeks. Hyaluronic acid suits a knee that aches on stairs and stiffens after sitting, taking two to six weeks to work and lasting three to six months, or longer if it is cross-linked and combined with collagen tripeptide. PRP suits younger, active patients with early osteoarthritis. No injection regenerates cartilage or cures osteoarthritis.

How it compares with your other options

Four kinds of injection are offered for a worn knee in Malaysia. Prices are typical private clinic ranges in 2026 for one knee, including the fee for the doctor.

Injection	What it does	Relief lasts	Typical cost	Best suited to
Corticosteroid	Switches off inflammation fast	4 to 12 weeks	RM 120 to RM 400	A hot, swollen, acutely painful flare
Hyaluronic acid	Restores the cushioning of joint fluid	3 to 6 months	RM 450 to RM 1,500	Mild to moderate osteoarthritis
Platelet-rich plasma	Uses your own platelets to damp inflammation	6 to 12 months after a course	RM 1,200 to RM 3,500	Younger, active patients with early wear
Hyaluronic acid with collagen tripeptide	Restores the fluid and reaches the cartilage	9 months to a year	RM 900 to RM 1,800	People who want one visit rather than a course

Scope of this claim. Prices quoted for treatments other than Chondroplus are market ranges observed in Malaysian private clinics, not our prices and not an offer. Chondroplus trade pricing is our own first-party price to clinics, excluding tax.

The full comparison, and which suits which knee

Questions patients ask

Is a knee injection painful?

Most people describe pressure rather than sharp pain. The needle is fine, the joint space is shallow at the front of the knee, and the whole injection takes under a minute. Your doctor may numb the skin first. Some aching for a day or two afterwards is normal.

How long before a knee injection starts working?

A corticosteroid usually works within one to three days. Hyaluronic acid is slower: expect two to six weeks before the full effect, because it works by restoring the fluid in the joint rather than switching off inflammation directly.

How many knee injections can I have?

There is no fixed lifetime limit for hyaluronic acid, and courses can be repeated once the effect wears off. Corticosteroid is different. Most doctors limit it to three or four injections in the same knee per year, because repeated steroid may itself harm cartilage.

Will an injection mean I can avoid knee replacement?

An injection does not reverse osteoarthritis or rebuild a worn joint. What it can do is control pain and improve movement, and for many people that defers surgery by months or years. In advanced disease with bone-on-bone change, injections tend to give shorter relief.

Can I drive or work after a knee injection?

Yes, in most cases you can walk out and go about the day. Doctors usually advise against running, squatting or heavy lifting for 48 hours so the material stays in the joint and settles.

Are knee injections covered by insurance in Malaysia?

Outpatient injections are often not covered by standard medical cards, which mainly pay for admissions. Some employer plans and takaful riders with outpatient specialist cover will reimburse. Ask your clinic for an itemised quotation with the procedure and the product listed separately before you claim.

Which knee injection is the most effective?

There is no single winner. Corticosteroid is the most effective at settling an acute, inflamed knee in the first weeks. Hyaluronic acid is more effective over three to six months. A cross-linked hyaluronic acid with collagen tripeptide is aimed at the longest interval from one visit. The right choice depends on whether your knee is inflamed now or mechanically painful over time.

Can I have hyaluronic acid and steroid together?

Some doctors inject a corticosteroid first to settle a flare, then give hyaluronic acid two to four weeks later to hold the improvement. Mixing them in the same syringe is not standard practice. Discuss the sequence with your doctor rather than asking for both at once.

What is the newest knee injection available in Malaysia?

The newest category widely available is cross-linked high molecular weight hyaluronic acid combined with collagen tripeptide, supplied as a single prefilled syringe. It differs from older products by adding a peptide that supports cartilage cells, alongside the lubricating effect of hyaluronic acid.

Do knee injections work for bone-on-bone arthritis?

They work less well and for less time. Where the X-ray shows no remaining joint space, an injection may still reduce pain enough to be worth doing, but the realistic effect is smaller and surgical options should be discussed in parallel.

Is a knee injection better than taking painkillers every day?

For most people with osteoarthritis, yes, on the safety side. A daily anti-inflammatory tablet exposes your stomach, kidneys and heart continuously. An injection puts a small dose into the joint where the problem is. Injections are also not a replacement for the exercise and weight work that changes the long-term picture.

Should I get an injection in both knees at the same time?

It is routine and saves a trip. Arrange transport home, and expect two days of quieter activity rather than one, since both legs will feel stiff. If money is tight, treating the worse knee first tells you how well you respond before you commit to the second.

Guides

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MY-CHP-2026-09-001. Date of preparation: September 2026. Intended for healthcare professionals and for patients seeking general information in Malaysia.